Research Progress on the Multitarget Mechanism of Dencichin Regulating the TGF-β/Smad and PI3K/Akt Pathways in Anti-Liver Fibrosis
DOI:
https://doi.org/10.56147/jbhs.3.1.124Keywords:
- Panax notoginseng,
- Liver fibrosis,
- Hepatic stellate cells,
- TGF-β/Smad,
- PI3K/Akt
Abstract
Liver fibrosis, a pathological process shared by various chronic liver diseases, is characterized by excessive deposition of extracellular matrix. Without intervention, it may progress to cirrhosis or even liver cancer. Panax notoginseng saponins, a key active component in the Chinese herb Panax notoginseng, have demonstrated significant potential in combating liver fibrosis in recent years. This review systematically summarizes the latest research advancements on the anti-fibrotic effects of Panax notoginseng saponins, focusing on their molecular mechanisms through multiple pathways including modulation of hepatic stellate cell activation, inhibition of inflammatory responses, reduction of oxidative stress and regulation of cell death. Additionally, the study discusses current research progress in structural modifications, dosage form innovation and combination therapies of Panax notoginseng saponins, while outlining challenges and future directions for clinical translation. The aim is to provide new insights for the in-depth development and clinical treatment of liver fibrosis.
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References
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