Exploring the Role of Generalized Health Biomarkers in Traumatic Brain Injury: A UK Biobank Study
DOI:
https://doi.org/10.56147/jbhs.2.5.74Keywords:
- Traumatic brain injury,
- Health biomarkers,
- UK biobank,
- Narrow-band TBI,
- Broad-band TBI,
- Injuries,
- Patients,
- Physiology,
- Alzheimer’s disease
Abstract
Background: The role of generalized health biomarkers remains widely unexplored in relation to Traumatic Brain Injury (TBI). However, they show association with worsened brain health and nervous system functioning. It is useful to explore potential relationship between TBI and generalized, circulating health biomarkers as surrogate endpoints that can be linked to severity and mortality.
Aim: This is a hypothesis-free study that investigates the potential relationship(s) between traumatic brain injury and 34 generalized, circulating health biomarkers using data collected by the UK Biobank.
Methods: Data from 419,778 white British participants are analyzed against 34 biomarkers from the UK Biobank database. TBI diagnosis is captured through ICD-10 codes and categorized as narrow-band and broad-band TBI. Multivariate linear regression analysis is conducted for changes in biomarkers in participants with TBI history vs. those with no history. This is analyzed across 4 models with increasing number of covariates and stratified for both categories of TBI.
Results: IGF-1, gamma glutamyltransferase and aspartase aminotransferase had significant results across all models in broad-band and narrow-band TBI (P<0.05). An additional ten biomarkers showed statistically significant results in all models except the fully adjusted models.
Conclusion: IGF-1, GGT and AST emerged as consistent indicators of systemic changes following TBI, highlighting their potential as surrogate markers for monitoring long-term outcomes. These findings suggest that incorporating generalized health biomarkers into clinical and research frameworks may improve early detection, risk stratification and intervention strategies in TBI populations.
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